PURE RETINOL 1% IN LUXURIOUS PLANT OILS
PURE RETINOL 1% IN LUXURIOUS PLANT OILS

Essentials

PURE RETINOL 1% IN LUXURIOUS PLANT OILS 30mL

With Squalane, Jojoba Oil (Organic), Hemi-Squalane, Grapeseed Oil, Vitamin E, Defensil Plus, Lipochroman and Cosmoperine.
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The most researched non-prescription Vitamin A derivative in a lightweight, fast penetrating, sensorially luxurious oil format. Stabilised with Lipochroman and Vitamin E. Boosted with Tetrahydropiperine. Soothed with Defensil Plus and calming extracts of Chamomile and Calendula. 

Formulated to help rejuvenate the appearance of the skin and give an overall improvement to skin texture. 

Manufactured / packaged under nitrogen, into airless containers. 

As we age our skin experiences a number of physiological changes such as thinning of the dermis and epidermis as well as a reduction in keratinocytes and collagen production. In addition to natural ageing, the skin is repeatedly exposed to environmental stressors such as UV radiation, pollution etc. Thinning of the dermis and epidermis results in a less effective skin barrier function and in turn leads to higher environmental stressors, higher trans-epidermal water loss and vulnerable skin. 

Retinol exhibits powerful anti aging action by increasing the production of keratinocytes (cells which produce keratin), endothelial cells (increases dermal vascularity) and fibroblasts (synthesizes collagen and extracellular matrix). 

This in turn leads to:
- Thickening of the epidermis
- Stimulation of collagen production
- Increase in skin firmness
- Increase in cellular renewal
- Decrease in fine lines and wrinkles

Retinol has shown to inhibit UV induced Matrix Metalloproteinases (enzymes which degrade collagen and prevent new collagen production).

Regulate oil production and reduce acne/blemishes.

Reduce collagenase.

Brightens skin tone.

Evens out skin tone.

Increases wound healing.

Considerably less erythema, irritation, TEWL, compared to tretinoin / retinoid acid.

Retinol boosts the effects of hydroxy acid peels due to increased cellular renewal, increased epidermal healing and enhanced penetration of the peeling agent. Retinol can be resumed after all evidence of peeling and irritation subsides.

References:
• J Invest Dermatol. 1995;105:549–56.
• Skin Res Technol. 1998 Nov;4(4):237-43.
• Nature. 1996 Jan 25;379(6563):335-9.
• N Engl J Med. 1997 Nov 13;337(20):1419-28.
• Journal of Cosmet Dermatol. 15, 49-57
• Clin Cosmet Investig Dermatol. 2015 Aug 26;8:455-61.
• Arch Dermatol. 2007;143(5)606-12
• Int J Cosmet Sci. 2017 Feb 39(1)56-65
• J Invest Dermatol. 1996 Aug;107(2):178-82.
• Skin Res Technol. 1998 Nov;4(4):237-43.
• J Invest Dermatol. 2000 Mar;114(3):480-6.

Warning – May cause irritation. Skin may also start to shed dead skin cells within the first week and may last a further week. 

Avoid direct and unprotected exposure to sun. 
DO NOT use during pregnancy. 
DO NOT use on sensitive skin conditions.

Directions

Introduce this serum into a skincare regime gradually.
Apply in the evening over serums and under face creams.
Keep skin moisturised with hydrating serums or face cream after use.


Avoid direct and unprotected exposure to sun.
DO NOT use during pregnancy.
DO NOT use on sensitive skin conditions.

Warning – May cause irritation. Skin may also start to shed dead skin cells within the first week and may last a further week.

Ingredients

Squalane (Plant derived), Simmondsia Chinensis (Jojoba) Oil (Organic), C13-15 Alkane (Hemi Squalane), Vitis Vinifera (Grape Seed) Oil,Caprylyl Caprylate/Caprate, Caprylic/Capric Triglyceride, Chamomilla Recutita (Chamomile) Extract (Organic), Calendula Officinalis (Calendula) Extract (Organic), Tocopheryl Acetate (Vitamin E), Octyldodecanol, Ribes Nigrum (Black Currant) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables, Cardiospermum Halicacabum Flower/ Leaf/Vine Extract, Tocopherol, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Retinol (1%), Tetrahydropiperine, Dimethylmethoxy Chromanol.

La Clinica For Skin and Body prides itself on its innovation and thus the ingredients listed here may differ from the packaging depending on the time and region of purchase.

Squalane (plant derived)

A powerful emollient with high oxidative stability found and created naturally in our skin. Squalane has occlusive properties yet is non-comedogenic and assists dry, inflamed skin conditions. It supports the skin’s barrier and has anti-bacterial properties. 


Simmondsia Chinensis (Jojoba) Oil (Organic)
Jojoba Oil is very similar to the sebum created by the sebaceous glands within the dermis. Sebum is fundamental for skin health. It assists in keeping the skin moisturised, maintains skin elasticity and preserves the skin’s barrier. Due to Jojoba oil’s sebum like qualities it is readily accepted and easily absorbed by our skin and has shown to be effective in enhancing the permeation and efficacy of the active ingredients it is combined with.
G Ital Dermatol Venereol. 2013 Dec;148(6):687-91
Curr Drug Deliv. 2017;14(3):426-432 

Jojoba oil exhibits high oxidative stability and resistant to premature degradation. Studies suggest Jojoba oil accelerates wound healing and stimulates collages synthesis.
J Ethnopharmacol. 2011 Mar 24;134(2):443-9.


C13-15 Alkane (Hemi Squalane)
A lightweight, ultra fast absorbing emollient derived from sugar.


Chamomilla Recutita (Chamomile) Extract (Organic)
Chamomile extract has strong anti-inflammatory effects on the skin. It inhibits nitric oxide production within the dermis. Nitric oxide is a catalyst for inflammatory diseases and is associated with acute and chronic inflammations. Chamomile extract has anti-oxidant and antimicrobial properties and has shown to enhance wound healing.
Electron Physician. 2016 Sep; 8(9): 3024–3031.
Int J Mol Med. 2010 Dec; 26(6): 935–940.

Wound healing (in-vivo)
Z Hautkr. 1987 Sep 1;62(17):1262, 1267-71.
J Wound Care. 2007 Jul;16(7):298-302.

Calendula Officinalis (Calendula) Extract (Organic)
Strong anti inflammatory action.
Indian J Exp Biol. 2009 Feb;47(2):113-20.

Wound healing (in-vivo)
J Wound Care. 2016 Dec 2;25(12):732-739.

Has shown to enhance collagen (in-vivo) and inhibit the activity of collagenase (in-vitro).
J Ethnopharmacol. 2017 Jan 20;196:94-103.

Has demonstrated protection against oxidative stress.
Phytother Res. 2015 Jan;29(1):120-4. 

Has shown to ameliorated the oxidant effects of cigarette smoke.
Toxicology and Industrial Health 2011 April 28(1):3-9

Tocopheryl Acetate (Vitamin E)
Anti-oxidant. Assists the stability of the natural oils and Retinol

Defensil Plus [Octyldodecanol, Ribes Nigrum (Black Currant) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables, Cardiospermum Halicacabum Flower/ Leaf/Vine Extract, Tocopherol, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract.]

A combination of Blackcurrant Seed Oil, Sunflower Oil and Ballon Vine Extract; To ease inflammation and support the recovery of the skin barrier (Group 2 & 3). Ballon vine extract a plant-derived alternative to hydrocortisone, soothes the skin.

• Protects and regenerates the damaged skin barrier (in-vivo study)

• Nips inflammatory processes in the bud (in-vitro study)

• Reduces allergic reaction (in-vitro study)

• Reduces tissue damage resulting from mosquito bites (in-vivo study)

• Soothes the skin after shaving and epilation (in-vivo study)

• Reduces the severity of couperose (in-vivo study)

Retinol (1%)

Cosmoperine [Tetrahydropiperine]
A patented natural permeation enhancer to increase the absorption and efficacy of actives in topical applications.

Dimethylmethoxy Chromanol
Also known as Lipochroman.

A potent anti oxidant that boosts the skin’s ability to resist oxidative damage due to external stressors and promotes the body’s natural detox process.

Demonstrated higher anti-oxidative power than well known anti-oxidants such as Ascorbic Acid (Vitamin C), Vitamin E and Coenzyme Q10. (Click here)

Provided potent singlet oxygen (ROS) scavenging activity.


 Boosted the expression of key players in the detoxification of environmental stressors and ROS. Helped boost skin’s ability to resist oxidative damage and enhance its elasticity, while also improving the appearance of aging signs (wrinkles and dark spots)

In this application it may assist the protection of retinol and natural oils from premature oxidation.

Shipping

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Will I have to pay any additional duties & taxes?

You will be liable for all import duties, customs and taxes levied by your country your order is being shipped to. These will be due at the point of, or after delivery.

We are not liable for these charges, and they unfortunately cannot be reimbursed or refunded by LA CLINICA FOR SKIN AND BODY.

If you are unsure of the charges and whether you will be affected, please contact your local customs office to find out more information.

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